Opisthorchis viverrini ov is a fishborne parasite endemic in parts of lao pdr, cambodia, southern vietnam and northeast thailand isaan where an estimated 10 million people are infected. The adult flukes deposit fully developed eggs that are passed in the feces. Opisthorchiidae from northeast thailand and laos pdr based on random amplified polymorphic dna analyses. In 198081, the prevalence in the north, northeastern, centre. Welcome to cdc stacks adult opisthorchis viverrini.
Pdf liver fluke disease is a chronic parasitic inflammatory disease of the bile ducts which is highly prominent in the tropical regions. Cdc opisthorchis resources for health professionals. Relationship between prevalence and intensity of opisthorchis viverrini infection, and clinical symptoms and signs in a rural community in northeast thailand. Opisthorchis viverrini is notable, because it is classi. Advances in the diagnosis of human opisthorchiasis. Liver flukes are platyhelminth parasites of the class trematoda, and opisthorchis viverrini o viverrini is a member of the family opisthorchiidae. Opisthorchis viverrini and other foodborne trematode infections are major health problems in thailand, the lao peoples democratic republic, vietnam and cambodia. Foodborne trematodiasis fbt is a significant global health problem, with the liver flukes opisthorchis viverrini, o. Frontiers granulin secreted by the foodborne liver. Opisthorchis viverrini infection in the snail and fish. Acquired resistance to opisthorchis viverrini in the hamster. Thewarach lahan, porntip pinlaort2, jason mulvennat3, banchob sripa2, manop sripa2, michael j smout3, robin b gasser4, paul j brindley5 and alex loukas3. The liver flukes endemic to asia and eastern europe include opisthorchis viverrini, clonorchis sinensis and o.
Specific diagnosis of opisthorchis viverrini using loop. Opisthorchis viverrini infection in the snail and fish intermediate hosts in central vietnam. Opisthorchiasis is a parasitic disease that can infect fish eating mammals, including humans. The guardians knowledge and attitudes about opisthorchis viverrini infection and. Opisthorchiidae is a family of digenean trematodes.
Deep sequencing in tandem with integrated genomicbioinformatic approaches identified more than 50 000 unique sequences being in each species. Montage of images relating to transmission of opisthorchis viverrini. Opisthorchis infection is a known cause of cholangiocarcinoma, bile duct cancer. Streptococcus bovis, clonorchis sinensis, opisthorchis viverrini, schistosoma haematobium, aspergillus flavus, aspergillus parasiticus, cancer, oncogenesis 1. Apr 30, 2018 opisthorchis viverrini has a complex life cycle in which eggs are excreted in the feces of the final hosts, usually humans, with cats and more rarely dogs also acting in this role 6, 12. Improved diagnostic methods for the detection of opisthorchis viverrini ov infection in humans is required for effective surveillance and control of this food borne parasite and the prevention of ovinduced bile duct cancer cholangiocarcinoma or cca. Studies on opisthorchis viverrini in thailand1 american. If the inline pdf is not rendering correctly, you can download the pdf file here. Research article prevalence of opisthorchis viverrini infection. Epidemiology of opisthorchis viverrini sciencedirect.
Foodborne trematodiasis fbt is a significant global health problem, with the liver flukes opisthorchis. This study analysed the patterns of infections of o. They have a knob at the abopercular end that may be prominent, inconspicuous, or absent. Available formats pdf please select a format to send. Medicallyproven carcinogenic parasites are three species of flukes, namely the urinary blood fluke schistosoma haematobium, the southeast asian liver fluke opisthorchis viverrini and the chinese liver fluke clonorchis sinensis. The liver fluke opisthorchis felineus oxford academic journals. The tumorigenic liver fluke opisthorchis viverrini. The liver fluke opisthorchis viverrini is a foodborne, zoonotic pathogen endemic to thailand and adjacent countries in southeast asia. Opisthorchis species are liver fluke parasites that humans can get by eating raw or undercooked fish, crabs, or crayfish from areas in asia and europe where the parasite is found, including thailand, laos, cambodia, vietnam, germany, italy, belarus, russia, kazakhstan, and ukraine. Epidemiology of opisthorchis viverrini infection request pdf.
In this study, a novel urinary antigen detection method was established for quantitative diagnosis of opisthorchiasis by a monoclonal. Imported opisthorchis viverrini and parasite infections. Frontiers current perspectives on opisthorchiasis control. Opisthorchis viverrini transmission models christine burli 1,2, helmut harbrecht2, peter odermatt1,2, somphou sayasone1,2,3, nakul chitnis1,2 1swiss tropical and public health institute, basel, switzerland 2universit at basel, basel, switzerland 3national institute of public health, vientiane, lao peoples democratic republic.
The opisthorchis viverrini genome functional genomics. The tumorigenic liver fluke opisthorchis viverrini multiple. Liver flukes infect the liver, gallbladder, and bile duct in humans. Updated molecular phylogenetic data for opisthorchis spp. Out of a total of 207 human participants, postanthelmintic treatment. Pdf the ecology of the bithynia first intermediate hosts of. Opisthorchis viverrini, adult worm image from ash, 1997. Microbiome compositional differences in cca were investigated based on 16s rrna profiling on paired tumornormal tissues for 32 nono. As a service to our customers we are providing this early version of the manuscript. A new strategy for controlling opisthorchiasis is needed because of issues such as drug resistance and reinfection.
Pdf the ecology of the bithynia first intermediate hosts. Files are available under licenses specified on their description page. Clonorchis sinensis adults are flattened, lance shaped, and measure approximately 10 to 25 mm long by 3 to 5 mm wide. Opisthorchis viverriniis a food borne trematode, important because of the sheer numbers of people infected and its serious morbidities such as hepatobiliary diseases and cholangiocarcinoma. Opisthorchiasis, highly prevalent in the isan region of northeastern thailand and laos. The species known as clonorchis sinensis has sometimes been reclassified into the genus opisthorchis. The eggs are ingested, probably together with fecal matter, by freshwater snails that act as first intermediate hosts. Carcinogenic parasite is a parasitic organism which depends on other organisms called hosts for their survival, and cause cancer in such hosts. Repeated praziquantel treatment and opisthorchis viverrini. May first report and molecular identification of opisthorchis viverrini infection in human communities from lower myanmar win pa pa aung 0 1 2 thi thi htoon 0 2 htay htay tin 0 2 kyi kyi thinn 0 2 oranuch sanpool 0 1 2 jurairat jongthawin 0 1 2 lakkhana sadaow 0 1 2 issarapong phosuk 0 1 2 rutchanee rodpai 0 1 2. Opisthorchis viverrini ov, a human liver fluke, is a pathologically and economically important foodborne trematode. Opisthorchis and metorchis, commonly referred to as liver flukes, are transmitted to humans and other mammals by the ingestion of fish infected with their larval stages which.
Research article open access a microrna profile associated with opisthorchis viverrini induced cholangiocarcinoma in tissue and plasma jordan plieskatt1,2, gabriel rinaldi1,2, yanjun feng1,2, jin peng1,2, samantha easley3, xinying jia4, jeremy potriquet4. The carcinogenic liver fluke opisthorchis viverrini is a. However, the mechanism by which the parasite is involved in carcinogenesis is not clear. By continuing to use our website, you are agreeing to our use of cookies. Opisthorchis viverrini wikipedia, a enciclopedia livre. Suppression of aquaporin, a mediator of water channel control. The oral and ventral suckers acetabulum are relatively small.
Refer to the help section for more detailed instructions. Clonorchis sinensis, opisthorchis felineus and opisthorchis viverrini are the three most important liver flukes involved in human health, infecting more than 45 million people worldwide. Gene discovery for the carcinogenic human liver fluke, opisthorchis viverrini. Opisthorchiasis is a parasitic disease caused by species in the genus opisthorchis specifically, opisthorchis viverrini and opisthorchis felineus. Imported opisthorchis viverrini and parasite infections from thai labourers in taiwan volume 67 issue 2 h. First report and molecular identification of opisthorchis. Cholangiocarcinoma, like opisthorchiasis, is highly prevalent in isan region of. Uncooked fish consumption among those at risk of opisthorchis. To identify parasite proteins central to liver fluke survival, the hostparasite relationship and the aetiology of cca, proteomic approaches were employed to characterise 300 o.
Mar 20, 2019 opisthorchis viverrini infection is highly prevalent in northeast thailand. People are infected after eating raw or undercooked fish. Get a printable copy pdf file of the complete article 855k. Infection with the parasite is called opisthorchiasis. Select up to three search categories and corresponding keywords using the fields to the right. Pdf immunology and molecular biology of opisthorchis. Opisthorchis viverrini medigoo health medical tests. Abstractopisthorchiasis is a neglected, tropical disease caused by the carcinogenic asian liver fluke. Epidemiology of opisthorchis viverrini in an endemic area. Opisthorchiidae have cosmopolitan distribution the most medically important species in the family opisthorchiidae are clonorchis sinensis, opisthorchis viverrini, and opisthorchis felineus, that are causes of the disease clonorchiasis some species are parasites of economically important fish, e. Specific diagnosis of opisthorchis viverrini using loop mediated isothermal amplification lamp targeting parasite microsatellites. Infection with opisthorchis liver flukes arises from the ingestion of raw or poorly cooked fish contaminated by these parasites.
Dao, ha thanh thi, veronique dermauw, sarah gabriel, apiporn suwannatrai, smarn tesana, giang thanh thi nguyen, and pierre dorny. Liver fluke infection with opisthorchis viverrini, opisthorchis felineus and clonorchis sinensis remains a major public health problem in many parts of asia and eastern europe. The liver fluke, opisthorchis viverrini, and the minute intestinal fluke, haplorchis taichui, are prevalent in many asian countries. Publishers pdf, also known as version of record citation for published version apa. Opisthorchis viverrini, a parasitic trematode, was recategorized as a group 1 biological carcinogen because it causes opisthorchiasis, which may result in cholangiocarcinoma. After ingestion, these liver flukes grow to adulthood inside the human biliary duct system. Fish sharing as a risk factor for opisthorchis viverrini infection. An integrated epidemiological study of opisthorchis viverrini consisting of risk factors analysis and parasitation prevalence determination in humans, as well as the assessment the roles of host reservoirs dogs and cats and intermediate hosts cyprinid fish was carried out in the vicinity of huay luang dam, udon thani province, in the north east of thailand. Introduction out of all of the infectious diseases worldwide, there are only a few microorganisms that have a welldefined mechanism associated with oncogenesis. The carcinogenic liver fluke opisthorchis viverrini is a reservoir for species of helicobacter asian pac j cancer prev, 16 5, 17511758 introduction cholangiocarcinoma cca is highly prevalent in asian countries, particularly in thailand, china, taiwan and korea shin et al. Genetic variation in opisthorchis viverrini trematoda.
In addition to the direct damage of the bile duct epithelium via direct contact with o. We performed an epidemiologic survey of opisthorchiasis in yangon, myanmar. This is a pdf file of an unedited manuscript that has been accepted for publication. In contrast to northern and northeastern thailand, central thailand was believed not to be endemic for opisthorchis viverrini ov. Cancer and infectious causes scientific research publishing. Introduction out of all of the infectious diseases worldwide, there are only a few microorganisms that have a. Opisthorchiasis from imported raw fish scienceopen. Ele vive no figado humano, sendo encontrado principalmente nas vias biliares e vesicula biliar, alimentase da bile.
Studies on opisthorchis viverrini in thailand1, american journal of epidemiology, volume 62, issue 2, 1 september 1955, pages 81115, we use cookies to enhance your experience on our website. Liver fluke infection caused by opisthorchis viverrini is a major public. Imported opisthorchis viverrini and parasite infections from. Opisthorchis viverrini infections and associated risk factors in a lowland area of binh dinh province. Trematodes flukes opisthorchis viverrini southeast asian liver fluke and opisthorchis felineus cat liver fluke. Clonorchis sinensis, the chinese liver fluke, is a liver fluke belonging to the class trematoda, phylum platyhelminthes. Population structure of opisthorchis felineus trematoda. Opisthorchis viverrini description, causes and risk factors.
Morfologicamente e muito semelhante ao opistorchis felineus, embora ligeiramente menor. In this paper, we describe variations of metacercarial infection with opisthorchis viverrini among cyprinid fish caught in endemic areas of southern cambodia. Opisthorchis viverrini and clonorchis sinensis a opisthorchis viverrini thailand is the most endemic country for opisthorchiasis due to o. Opisthorchis felineus as a typical representative of the family. It was discovered by a british physician james mcconnell at the medical college hospital in calcutta kolkata in 1874. Lesions caused by the feeding activities of the liver fluke represent wounds that undergo protracted cycles. After ingestion by a suitable snail first intermediate host, the eggs release miracidia, which undergo in the snail several developmental stages sporocysts, rediae. Clonorchis and opisthorchis clonorchis sinensis, opisthorchis viverrini, and o. Late complications of infection with opisthorchis viverrini. We hypothesized that the behaviouralpsychosocial background of the study population might play an. Opisthorchis felineus has been documented in at least 12 countries of the european union, belarus, ukraine, and in western siberia russia. First report and molecular identification of opisthorchis viverrini infection in human communities from lower myanmar plos one, dec 2019 win pa pa aung, thi thi htoon, htay htay tin, kyi kyi thinn, oranuch sanpool, jurairat jongthawin, lakkhana sadaow, issarapong phosuk, rutchanee rodpai, pewpan m. Although treatment with praziquantel pzq effectively cures o. From the greek opisthen behind and orchis testicle, opisthorchis is a genus of trematode flatworms.
Fieldwork conducted in a rural area of central thailand revealed that the prevalence and incidence were relatively high compared with regional average data. Fish sharing as a risk factor for opisthorchis viverrini. Seasonal variation of opisthorchis viverrini metacercarial infection. Increased cell proliferation of mouse fibroblast nih3t3. Recently, loopmediated isothermal amplification lamp has been widely used for detection and identification of trematode for its simple method that is.
A microrna profile associated with opisthorchis viverrini. Clonorchis sinensis, opisthorchis viverrini, and o. Opisthorchiasis caused by opisthorchis viverrini, is of considerable public health importance in southeast asia, particularly in lao pdr and thailand sripa et. Opisthorchiasis and opisthorchisassociated cholangiocarcinoma in. O viverrini is highly prevalent in thailand and laos while c. The tumorigenic liver fluke opisthorchis viverrini multiple pathways.
May 14, 2014 opisthorchis viverrini is highly endemic in southeast asia, where more than 10 million people are infected 1, 2. Media in category opisthorchis viverrini the following 7 files are in this category, out of 7 total. All structured data from the file and property namespaces is available under the creative commons cc0 license. In thailand and neighbouring countries, human opisthorchiasis is caused by o. Patterns of trematode infections of opisthorchis viverrini. Although infections are identified throughout southeast asia, the epicenter is northeast thailand, where high prevalence coexists with a high. Tissue microbiome profiling identifies an enrichment of. Opisthorchis viverrini is found mainly in northeast thailand, laos, cambodia, and central and southern vietnam. In humans, it infects the common bile duct and gall bladder, feeding on bile. Pdf opisthorchis viverrini liver fluke as the lot of baleful parasite.
This article is from nature communications, volume 5. Epidemiology of opisthorchis viverrini in an endemic area of. Opisthorchis viverrini medigoo health medical tests and. Two groups of ten hamsters received a primary challenge of five opisthorchis viverrini metacercariae intragastrically groups i and iii and a third we use cookies to enhance your experience on our website. Opisthorchis viverrini, common name southeast asian liver fluke, is a foodborne trematode parasite from the family opisthorchiidae that infects the bile duct. Infections are not known to persist beyond 2530 years, the. This liver fluke is classified as a carcinogen due to its causal links with cholangiocarcinoma cca development. Chronic infection may lead to cholangiocarcinoma, a malignant cancer of the bile ducts. Research highlights opisthorchis viverrini, fishborne parasite infection liver fluke.
The opisthorchis viverrini genome provides insights into. Morphologic appearance of different stages of opisthorchis viverrini flukes. Gene discovery for the carcinogenic human liver fluke. These pathogen safety data sheets, regulated under workplace hazardous materials information system whmis legislation, are produced for personnel working in the life sciences as quick safety reference material relating to infectious microorganisms. Endemicity of opisthorchis viverrini liver flukes, vietnam. Pdf opisthorchis viverrini and opisthorchis felineus researchgate. The two testes are located posterior to the ovary, and are highly brancheda feature which separates it from the related opisthorchis spp. Opisthorchis viverrini oxford academic journals oxford university.
Opisthorchis viverrini has a complex life cycle in which eggs are excreted in the feces of the final hosts, usually humans, with cats and more rarely dogs also acting in this role 6, 12. Liver flukes are platyhelminth parasites of the class trematoda, and opisthorchis viverrini o viverrini is a. The liver flukes opisthorchis felineus rivolta, 1884, o. Infection by opisthorchis viverrini is a strong risk factor for cholangiocarcinoma.
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